Inflammation

Dr. M’s Women and Children First Podcast #86 – Joe Pizzorrno, ND

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Welcome to Dr. M’s Women and Children First, the podcast where we dive deep into the science of health, wellness, and prevention—especially for women, children, and families. Today, we have a truly special guest, Dr. Joe Pizzorno.

Dr. Joe Pizzorno is a world-renowned leader in functional and naturopathic medicine, a trailblazer in environmental health, and the founding president of Bastyr University, one of the most prestigious natural health institutions in the world. With decades of research, policy advocacy, and clinical expertise under his belt, Dr. Pizzorno has been at the forefront of reshaping modern medicine by emphasizing the critical role of nutrition, detoxification, and whole person health in preventing and reversing disease.

He is the author of these books: Textbook of Natural Medicine, The Toxic Solution, Clinical Environmental Medicine, Clinical Pathophysiology and Total Wellness. He is an incredible teacher and sought after speaker worldwide.

Today, we’ll be discussing metabolism and the hidden impact of environmental toxins on women and children’s health, practical detox strategies, and how we can take charge of our well-being in an increasingly toxic world. If you’re looking for science-backed insights and actionable tips to help your family thrive, you won’t want to miss this conversation!

I hope that you enjoy my conversation with Dr. Joe Pizzorno!

Dr. M

Dr. M’s Women and Children First Podcast #14 Repost- Richard Johnson MD – Nature Wants Us to Be Fat

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

This is a repost of the most listened to podcast with Richard J. Johnson, M.D.. Dr. Johnson is the Tomas Berl Professor of Medicine and the Chief of the Renal Division and Hypertension at the University of Colorado since 2008. A graduate of the University of Wisconsin, Madison, with a major in Anthropology, and a graduate of the University of Minnesota Medical School, Minneapolis, he is a physician and nephrologist whose research has focused on the role of sugar, and especially fructose, in driving obesity, diabetes, high blood pressure and kidney disease. Much of this work has explored the role of fructose metabolism, especially the generation of uric acid, in driving this phenotype, and his work has included studies ranging from molecular biology, integrative physiology, and evolutionary biology. He is the author of The Sugar Fix which introduced the first low fructose diet, and also The Fat Switch which explores the role of fructose in driving the obesity epidemic. His newest book, Nature Wants Us To Be Fat, is a tour de force of the entire pathway of survival via metabolic events in the body related to fructose and the polyol pathway. This is a must read book. This podcast will introduce you to the exceptional work of Dr. Johnson and how we are now mismatched metabolically for the environment of modern America and our food systems.

Please enjoy this wide ranging conversation.

Dr. M

Dr. M’s SPA Newsletter Volume 14 Issue 50

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

“Life forms on our planet have evolved under the strong influence of a daily light/dark cycle. Sunlight being the primary source of energy for photosynthesis, the daily production of photosynthetic biomass has a predictable diurnal rhythm. The daily cyclical production of photosynthesized chemical energy is at the base of the food chain. Daily changes in light and darkness result in diurnal rhythms in other environmental parameters such as temperature and humidity. Such a predictable and robust daily rhythm in food availability and environmental factors has led to the evolution of a ~24 h internal timing mechanism or circadian rhythm to enable organisms to anticipate daily changes and to optimize fitness. Fundamental to this 24 h rhythms is the ability to acquire food when it is available and to store a portion of these resources for utilization during the rest of the day (i.e. the fasting period) without compromising fitness and vitality. The fasting period also serves as a time for standby and repair so that the organism is fit and competent to harvest energy when light (for photosynthetic organisms) or food becomes available. While many non-photosynthetic lifeforms with short lifespan (< a few days) may not derive profound benefit from a circadian timing system, they share fundamental biochemical mechanisms for acquiring and storing food when it is available and then utilizing this stored energy during a quiescent period of fasting for repair, stress resistance and vitality.” (Longo et. al. 2016)

This is the crux of the understanding that we, the homo sapiens on Earth, need to realize that biology trumps any desire that we may have to fight against it. We are and have been moving in the wrong direction for quite some time as it relates to what we were meant to do biologically as children and then adults. Not coordinating activity with the sun is a negative recipe for health. Third shift workers are the canary’s in the coal mine for the risks of working and being awake when the sun is down and sleeping when it is up. This population has some very high risks for metabolic disease based on the data. (Biggi et. al. 2008)

Plus a section on filaggrin genes and skin function.

Dr. M

Dr. M’s SPA Newsletter Volume 14 Issue 47

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Sulfurophane and health – It is clear now that SFN stands out as a powerhouse phytochemical with profound effects on human health through the pathway of nurclear factor erythroid related 2 (NRF2). It is found abundantly in cruciferous vegetables such as broccoli, broccolini, kale, and brussels sprouts. SFN is a bioactive compound with impressive clinical potential for preventing chronic disease and optimizing cellular health, especially in oxidant impaired/overloaded states. At its core, SFN is a sulfur-rich molecule derived from glucoraphanin, a glucosinolate precursor. The transformation occurs when the enzyme myrosinase, released during the chopping or chewing of cruciferous vegetables, catalyzes the reaction. Interestingly, this enzymatic activation can also be achieved via gut microbiota when raw vegetables are absent from the diet, emphasizing the remarkable adaptability of our biology to source essential nutrients as needed for survival. (Ali et. al. 2023)

Nrf2 is a master regulator of cellular defense, orchestrating the production of detoxification enzymes, antioxidants, and other cytoprotective proteins. By activating Nrf2, sulforaphane enhances the body’s resilience to oxidative stress, a key contributor to aging, inflammation, and the development of chronic diseases such as cardiovascular disease and diabetes. Studies reveal that sulforaphane also induces Phase II detoxification enzymes, such as glutathione S-transferase, which play a vital role in neutralizing and excreting harmful toxins.

Dr. M’s SPA Newsletter Volume 14 Issue 46

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Lymphatics – Refresher

Lymphatics – a plumbing system that follows the circulatory system throughout the body including the brain where it is called the glymphatics. The function of these passively moving tubes is to transport fats around the body, clear cellular debris returning it to the liver and spleen, move fluid in and out of tissue to maintain fluid balance, transport and help immune cells function. By transporting fats , lymph is involved in vitamin movement to tissues and cells for Vitamins A, D, E, K. These are critical functions of metabolism, immunity and detoxification that when disrupted lead to chronic diseases of aging including edema, hypertension, autoimmunity and cardiovascular disease.

“Traditionally considered a passive route for transport of fluid, immune cells, and lipoproteins, lymphatics are now known to be active players in major physiological and pathophysiological processes. Until recently, lymphatic vessel dysfunction was mainly associated with primary and secondary lymphedema. Unexpectedly, however, lymphatic vascular defects have been uncovered in conditions such as obesity, cardiovas- cular disease, inflammation, hypertension, atherosclerosis, Crohn’s disease, glaucoma and various neurological disorders such as Alzheimer’s disease.” (Oliver et. al. 2021)…and a discussion on chemicals in school food.

Enjoy,

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 39

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Section I

Understanding the Action and Use of GLP-1 Agonists in Children – A Pediatrician’s Viewpoint

The United States, like much of the developed world, is facing increasing rates of childhood obesity and related health concerns. Despite years of research and various efforts, addressing this public health issue remains a complex challenge.

This article reviews the potential mechanisms, benefits, and considerations for using GLP-1 agonists in children based on the current scientific understanding. While early research is promising, the application of these treatments in children requires careful consideration and should always be done in consultation with a healthcare provider.

As a pediatrician, I recognize that while the science behind these treatments is evolving, it’s important to remember that individual responses to treatments can vary. For children, every approach needs to be carefully weighed, considering their unique developmental needs…..

Enjoy,

Dr. M

Dr. M’s Women and Children First Podcast #79 – Robert Lustig, MD – Obesity Epidemic

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Welcome to the podcast! Today, I am thrilled to have a true pioneer in the field of metabolic health, Dr. Robert Lustig, MD, joining us. Dr. Lustig is a neuroendocrinologist and Professor Emeritus of Pediatrics in the Division of Endocrinology at the University of California, San Francisco. He is best known for his groundbreaking work on the intersection of diet, obesity, and metabolic disease, particularly his deep dive into the role of sugar as a driving force behind many of today’s chronic health issues.

As the author of several influential books, including Fat Chance, The Hacking of the American Mind and Metabolical, Dr. Lustig has been a vocal advocate for public health, helping to raise awareness about the harmful effects of processed foods, particularly refined sugars. His research has been instrumental in shifting the conversation around nutrition, focusing on the biological impacts of sugar and the ways it contributes to insulin resistance, obesity, and metabolic syndrome. His most recent paper entitled Obesogens, A Unifying Theory for the Global Rise in Obesity in the International Journal of Obesity – Nature is a ground stirring take on the current research.

We are excited to explore his latest insights into metabolic health and the science of obesity, and how we can apply this knowledge to improve our own well-being. Let’s welcome Dr. Lustig to the show!

Dr. M

1 2 … 4