maternal child health

Dr. M’s Women and Children First Podcast #62 – Jeff Bland, Ph.D. – The Disease Delusion and Hope for Change

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Podcast #62
Jeff Bland, Ph.D.
This week I have the absolute pleasure to introduce you to Dr. Jeff Bland. He is in a word, incredible.
Dr. Bland is supreme thinker in the field of medicine and biology. He is a teacher, product developer, thought leader, unifier of minds and so much more. He obtained his BS in Biology at the University of California at Irvine and then a PhD from the University of Oregon. Dr. Bland was thinking about medicine from a root cause perspective decades before it became more vogue to believe in Integrative medicine. He is the founder of the Institute for Functional Medicine as well as his new company Big Bold Health, a company on a mission to transform the way people think about one of nature’s greatest innovations — the immune system. With Big Bold Health, he is pushing for the power of cellular immuno-rejuvenation through food to enhance immunity at a human level. The key is the rediscovery of ancient food crops and superfoods that have these properties of health promotion.
We wander the landscape of human health through bramble and brook without a care in the world. It is a most enjoyable conversation to share.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 50

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Literature Review
1) Pericytes are critical cells that sit around the tiny blood vessels called capillaries of the body especially in the brain. They are involved in regulating blood vessel activity. They communicate directly with the endothelial cells making them super important in the activity of the blood vessel and metabolism at the local tissue interface. From the journal Cell Death and Disease we see: “Crosstalk mechanisms….And some other discussions on Cancer detection at physicals as well as the recipe of the week.
Enjoy,
Dr. M

Dr. M’s Women and Children First Podcast #60 – Moshe Szyf, Ph.D. – Hope and Epigenetics Part 2

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This week’s guest is Professor Moshe Szyf.
This is the second story of hope for us as a species. We have a level of control over our outcome that is baked into our DNA.
Dr. Moshe Szyf joins the show today to discuss the social programming of the epigenome. Dr. Szyf and his colleague Dr. Meaney proposed over two decades ago the first set of evidence that the “social environment” early in life can alter DNA methylation launching the emerging field of “social epigenetics”. He also has illustrated that DNA methylation is a prime therapeutic target in cancer and other diseases to be explored and potentially manipulated for health.
“Together, they discovered that our genetic code, the actual sequential structure of our DNA, can pretty much shrug off the influence of any external environmental factors, short of massive radiation. However, the expression of individual genes within that sequence can be permanently altered by such seemingly innocuous influences as diet or how others treat us. Once triggered, a group of molecules called a methyl group attaches itself to the control centre of a gene, permanently switching on or off the manufacture of proteins that are essential to the workings of every cell in our body. In most tumours, this DNA methylation pattern has been knocked awry, leading to a gene being completely deactivated or triggered to abnormally high activity.” (McGill Reporter)
Dr. Szyf received his Ph. D from the Hebrew University and did his postdoctoral fellowship in Genetics at Harvard Medical School before he joined the department of Pharmacology and Therapeutics at McGill University in Montreal, Canada. He currently holds the James McGill Professorship in Pharmacology. He is the founding co-director of the Sackler Institute for Epigenetics and Psychobiology at McGill and is a Fellow of the Canadian Institute for Advanced Research Experience-based Brain and Biological Development program. Szyf has been the founder of the first “Pharma” to develop epigenetic pharmacology “Methylgene Inc.” and the first journal in epigenetics “Epigenetics”.
Please enjoy my conversation with Dr. Moshe Szyf,
Enjoy,
Dr. M

Dr. M’s Women and Children First Podcast #59 – Randy Jirtle, Ph. D. – The Imprintome and Hope

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Randy Jirtle, Ph.D.
This week’s guest is Professor Randy Jirtle.
Dr. Randy Jirtle joins the show for the second time today to discuss his new research on the imprintome, the regulatory regions that at the earliest stages of fetal development control our epigentic and thus our genetic outcome. This is the Hope locus.
Time Magazine nominated him for person of the year in 2007 and had this to say about him: “Dr. Jirtle’s pioneering work in epigenetics and genomic imprinting has uncovered a vast territory in which a gene represents less of an inexorable sentence and more of an access point for the environment to modify the genome. His trailblazing discoveries have produced a far more complete and useful understanding of human development and diseases” — Time Magazine. This interview is ground zero for the Women and Children First Podcast as we discuss the underpinnings or mechanisms of disease risk for all humans as it relates to the environmental inputs of our lives that are driving health or disease at both the pregnancy and post natal periods. We look specifically at how maternal nutrition and later chemical exposure directly affected the health of the agouti mouse offspring. This experiment was the first of its kind and paved the way for a complete shift in human disease understanding. For parents, this podcast is really the beginning of everything that I am trying to convey regarding a healthy pregnancy and childhood. Without this interview, the following interviews will be more difficult to understand. The picture becomes very clear once his research is cemented in our minds.
His biography is as follows: Professor of Epigenetics at the Department of Biological Sciences, North Carolina State University, Raleigh, NC, and a Senior Scientist at McArdle Laboratory for Cancer Research at the University of Wisconsin, Madison, WI. He was previously professor of radiation oncology and associate professor of pathology at Duke University, Durham, NC, where he had been a faculty member since 1977. He graduated with a B.S. degree in nuclear engineering in 1970 and a Ph.D. degree in radiation biology in 1976, from the University of Wisconsin-Madison. His awards list is long but the key to Dr. Jirtle is that he is a curious thinker and we are grateful for this.
Please enjoy my conversation with Dr. Randy Jirtle,
Enjoy,
Dr. M

Dr. M’s Women and Children First Podcast #58 – Mahmoud Ghannoum, Ph. D. – Microbiomes – Bacterial and Fungal

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This week’s guest is Professor Mahmoud Ghannoum. For over four decades, Dr. Ghannoum has been exploring a critical but neglected inhabitant of the human body, the fungus. Born and raised in Lebanon, Dr Mahmoud Ghannoum is the current Director of the Center for Medical Mycology at Case Western Reserve University. He began his scientific journey at Loughborough University in England where he studied the fungus candida and its health associated diseases. Coupling this work to his curiosity about the whole area of intestinal microorganisms in the human body, he has become one of the leading researchers in the world in this space.
His discoveries include the knowledge that fungal organisms constitute an essential part of the microbiome. In fact, in 2010, Dr Ghannoum was the first scientist to identify over 100 native species of fungi in the oral cavity and that they are mostly friendly to us. Like with bacteria, there are good fungi as well as bad fungi. And just as it was startling to discover that we need positive bacteria in our guts, most people today are shocked to learn that their health depends on flourishing colonies of helpful fungi. Symbiosis in all things seems to be the flavor of the day and history has proven this to be what we should have always assumed.
He is widely published in top journals as well as being the founder and director of Biohm, a company dedicated to microbiome analysis and management from the perspective of fungal and bacterial communities. He is the author of Total Gut Health. This week, Dr. Ghannoum and I look critically at the microbiome of humans from the well trafficked bacterial road to the less travelled fungal road.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 40

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Maternal Microbiome Part II
Mom has a gut microbiome that directly seeds her babies microbiome. This microbiome dictates human long term and short term health. Eating a diet loaded with fiber based fruits, legumes and vegetables will cause a highly diverse bacterial microbiome to exist and this existence is correlated with better long term health……plus a section on mate matching as well as the recipe of the week!
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 39

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Maternal Nutrition and the Microbiome – Part I

This was a tricky topic to drill down into one article – so I split it into two. Bear with me on this topic as it is so important in the grander scheme of maternal and child health.
The microbiome by definition: the microorganisms that reside in a particular environment.
Pregnancy is a dynamic event where a woman’s body changes radically, including epigenetically, hormonally, immunologically and physiologically in order to conceive and carry a baby to term. Pregnancy has always been a scientific fascination because of these changes. Now, we add the microbiome to the list, as it is the latest area of research that is shedding light on how pregnancy outcomes are determined.
Part I
This was a tricky topic to drill down into one article – so I split it into two. Bear with me on this topic as it is so important in the grander scheme of maternal and child health. The microbiome by definition: the microorganisms that reside in a particular environment. Pregnancy is a dynamic event where a woman’s body changes radically, including epigenetically, hormonally, immunologically and physiologically in order to conceive and carry a baby to term. Pregnancy has always been a scientific fascination because of these changes. Now, we add the microbiome to the list, as it is the latest area of research that is shedding light on how pregnancy outcomes are determined…… also two sections on covid vaccines and disease…
Enjoy,
Dr. M

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