Tag Archives: disease

Dr. M’s Women and Children First Podcast #83 – Ana Maria Temple, MD

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Dr. Ana-Maria Temple, MD, is an integrative pediatrician known for her whole child approach to children’s health. She studied medicine at the University of North Carolina at Chapel Hill School of Medicine before pursuing pediatric residency training at Penn State Milton S. Hershey Medical Center. In 2017, Dr. Temple further specialized by completing a fellowship in Functional Medicine at the Cleveland Clinic Foundation. She combines conventional medicine with functional and lifestyle-based strategies to address common childhood conditions such as eczema, asthma, and allergies. Dr. Temple has a particular focus on helping families reduce dependence on medications by making sustainable health and wellness changes.

With decades of clinical experience, Dr. Temple has been a vocal advocate for preventive care, emphasizing nutrition, environmental changes, and integrative treatments. She is the author of the two bestselling books Healthy Kids in an Unhealthy World and Ending the Eczema Epidemic. Additionally, Dr. Temple is a sought-after speaker and podcast guest, sharing her expertise on holistic pediatric care through various platforms. Today, we focus on her approach to eczema and children’s health.

Enjoy,

Dr. M

Dr. M’s SPA Audiocast Newsletter Volume 14 Issue 28

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Klotho Part II

Last week we discussed Klotho as a protein that has pleotrophic effects in the body as it relates to cellular aging. This week let us focus specifically on the brain. What are the effects of klotho as it relates to cognition and function over time? Klotho has neuroprotective effects based on studies that show that better cognitive performance in translational models over time occur with the injections of klotho. Klotho is also shown to have neuroprotective effects if naturally elevated, i.e. individuals with host genetics that promote more klotho production over time without being taken or given.

The pivitol research occurred in 2015 in a mouse model of Alzheimers Disease (AD) where Dr. Dena Dubal and colleagues looked at two groups of intervention mice with and without higher levels of Klotho. and a literature review on micro plastics and screentime.

Enjoy,

Dr. M

Dr. M’s SPA Audiocast Newsletter Volume 14 Issue 27

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Klotho Part I
Ok, it is time for a potential log step shift in the human understanding of neurological decline with age starting from birth.
Enter the peptide, (C)Klotho, named after the greek goddess of fate who spins the thread of life for all. The Klotho protein was discovered by researchers looking at mice that aged faster than the general mouse population. These mice were noted to have a shortened lifespan, stunted growth, renal disease, blood vessel calcification, cardiac hypertrophy, hypertension, pulmonary disease, cognitive impairment, multi-organ atrophy and fibrosis. (Prud’homme et. al. 2022) When they looked closer, these mice were found to have hypoactive klotho proteins leading to an explosion of research over the past two decades to understand why. The next question was, could the hyperactive state provide an anti aging effect?
The answer was a resounding yes!
and a discussion on fast food.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 22

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What are the main preventable etiologies for childhood death under the age of five years?
According to the data compile by UNICEF, we see the following for the world:
1) Prematurity 18%
2) Pneumonia 14%
3) Birth Asphyxia 12%
4) Malaria 9%
5) Diarrhea 9%
6) Congenital anomolies 8%
7) Injuries 5%
8) Blood infections/sepsis 3%
9) Tuberculosis 3%
10) all others
From a global perspective, we are on the right track as deaths have decreased significantly from 12 million in 1990 to less than 5 million annually in 2022. This is a massive improvement in global childhood health. More work to be done as pneumonia and diarrhea based death should be less than 1%. Access to clean water, clean medicines and adequate medical care could crush these issues….plus a literature review as well as an ode to mothers.
Enjoy,
Dr. M

 

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 21

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Excess Weight Gain, Obesity and Immune Related Diseases in 2 cases
I want to share a few recent case experiences that shed light on the patient provider experience in the context of a collaborative clinic model based on prevention and the patient first mentality.
In the struggle against the US based disease onslaught that is excess weight gain, longevity with the patient remains the greatest winner for a quality outcome. What do I mean when I say this? Let me tell you a story. I care for a wonderful young man who is about to turn 17 years old. I have known him since birth and his struggle with weight has been profound for most of these 17 years…… Plus an article review about weight loss and a recipe of the week.
Enjoy,
Dr. M

Dr. M’s Women and Children First Podcast #63 – David Clarke, M.D. – Pain, Psychology and Trauma

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This weeks guest is Dr. David D. Clarke. Dr. Clarke is President of the Psychophysiologic Disorders Association where he teaches the science of the mind body connection as it relates to GI related diseases that do not fit a traditional diagnostic nor pathological framework. For three plus decades, he conducted detailed interviews with over 7000 people whose symptoms were not explained by diagnostic testing, but were significantly affecting their lives in a negative way. He realized that these individuals often suffered from severe traumas in childhood that built the foundation of current health struggles. We dive into his work and the successes built upon the recognition of, intervention for and resolution related to the issues and physiological manifestations of disease.

Dr. Clarke graduated from Williams College with honors before attending the University of Connecticut School of Medicine where he received his medical degree and the Mosby Award for Clinical Excellence.  He completed internship and residency in Internal Medicine and fellowship in Gastroenterology at Harbor/UCLA Medical Center in Los Angeles. Dr. Clarke has lectured extensively on Psychophysiologic Disorders to specialists and the public across North America and Europe. He has appeared on syndicated broadcasts hosted by Rosie O’Donnell, by Montel Williams and by Michael Roizen(author of You: The Owner’s Manual).

He is the Author of “They Can’t Find Anything Wrong” and co-author of “A Diagnostic Guide for Psychophysiological Disorders” and Psychophysiologic Disorders”.

Please enjoy my conversation with Dr. David Clarke,

Dr. M

Dr. M’s Women and Children First Podcast #60 – Moshe Szyf, Ph.D. – Hope and Epigenetics Part 2

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This week’s guest is Professor Moshe Szyf.
This is the second story of hope for us as a species. We have a level of control over our outcome that is baked into our DNA.
Dr. Moshe Szyf joins the show today to discuss the social programming of the epigenome. Dr. Szyf and his colleague Dr. Meaney proposed over two decades ago the first set of evidence that the “social environment” early in life can alter DNA methylation launching the emerging field of “social epigenetics”. He also has illustrated that DNA methylation is a prime therapeutic target in cancer and other diseases to be explored and potentially manipulated for health.
“Together, they discovered that our genetic code, the actual sequential structure of our DNA, can pretty much shrug off the influence of any external environmental factors, short of massive radiation. However, the expression of individual genes within that sequence can be permanently altered by such seemingly innocuous influences as diet or how others treat us. Once triggered, a group of molecules called a methyl group attaches itself to the control centre of a gene, permanently switching on or off the manufacture of proteins that are essential to the workings of every cell in our body. In most tumours, this DNA methylation pattern has been knocked awry, leading to a gene being completely deactivated or triggered to abnormally high activity.” (McGill Reporter)
Dr. Szyf received his Ph. D from the Hebrew University and did his postdoctoral fellowship in Genetics at Harvard Medical School before he joined the department of Pharmacology and Therapeutics at McGill University in Montreal, Canada. He currently holds the James McGill Professorship in Pharmacology. He is the founding co-director of the Sackler Institute for Epigenetics and Psychobiology at McGill and is a Fellow of the Canadian Institute for Advanced Research Experience-based Brain and Biological Development program. Szyf has been the founder of the first “Pharma” to develop epigenetic pharmacology “Methylgene Inc.” and the first journal in epigenetics “Epigenetics”.
Please enjoy my conversation with Dr. Moshe Szyf,
Enjoy,
Dr. M

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