Tag Archives: klotho

Dr. M’s SPA Audiocast Newsletter Volume 14 Issue 28

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Klotho Part II

Last week we discussed Klotho as a protein that has pleotrophic effects in the body as it relates to cellular aging. This week let us focus specifically on the brain. What are the effects of klotho as it relates to cognition and function over time? Klotho has neuroprotective effects based on studies that show that better cognitive performance in translational models over time occur with the injections of klotho. Klotho is also shown to have neuroprotective effects if naturally elevated, i.e. individuals with host genetics that promote more klotho production over time without being taken or given.

The pivitol research occurred in 2015 in a mouse model of Alzheimers Disease (AD) where Dr. Dena Dubal and colleagues looked at two groups of intervention mice with and without higher levels of Klotho. and a literature review on micro plastics and screentime.

Enjoy,

Dr. M

Dr. M’s SPA Audiocast Newsletter Volume 14 Issue 27

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Klotho Part I
Ok, it is time for a potential log step shift in the human understanding of neurological decline with age starting from birth.
Enter the peptide, (C)Klotho, named after the greek goddess of fate who spins the thread of life for all. The Klotho protein was discovered by researchers looking at mice that aged faster than the general mouse population. These mice were noted to have a shortened lifespan, stunted growth, renal disease, blood vessel calcification, cardiac hypertrophy, hypertension, pulmonary disease, cognitive impairment, multi-organ atrophy and fibrosis. (Prud’homme et. al. 2022) When they looked closer, these mice were found to have hypoactive klotho proteins leading to an explosion of research over the past two decades to understand why. The next question was, could the hyperactive state provide an anti aging effect?
The answer was a resounding yes!
and a discussion on fast food.
Enjoy,
Dr. M